“Among the enemies which the church has here upon earth,the antichrist is the most significant and primary cause of all the persecutions of the church.
The word “antichrist” consists of two words: [Greek word–CD] (anti), which, depending on the context, can mean either against or for, and [Greek word–CD] (Christos). Thus the word “antichrist” pertains to someone who is against Christ but who nevertheless creates the impression as if he were for Christ.
Sometimes this word is used as pertaining to every heretic, who opposes the Person and the doctrine of Christ. “As ye have heard that antichrist shall come, even now are there many antichrists; whereby we know that it is the last time” (1 John 2:18).
Generally, however, it pertains to the great antichrist, the head of the multitude who oppose the doctrine and professors of Christ. That such a person will come is confirmed by many texts in the Holy Scriptures and is a fact which is not denied by anyone.
Question: Who is the antichrist?
Answer: With all Protestants we reply: The pope of Rome. The papists deny this strongly” (Wilhelmus a’Brakel, The Christian’s Reasonable Service).