“And call on Me in the day of distress, and I will save you; and you shall glorify Me” (Psalm 50:15).
“Trust in Him at every time, you people; pour out your heart before Him; God [is] a refuge for us. Selah” (Psalm 62:8).
“Rejoice always. Pray without ceasing. In everything give thanks, for this [is the] will of God in Christ Jesus toward you” (1 Thessalonians 5:16-18).
“And likewise the Spirit also joins in to help our weaknesses. For we do not know what we should pray as we ought, but the Spirit Himself intercedes on our behalf with groanings that cannot be uttered. But the [One] searching the hearts knows what [is the] mind of the Spirit, because He petitions on behalf of [the] saints according to God” (Romans 8:26-27).
“And [by] the superabundance of the revelations, that I not be made arrogant, a thorn in the flesh was given to me, a messenger of Satan, that he might buffet me, that I not be made haughty. Beyond this I entreated the Lord three times, that it depart from me. And He said to me, My grace is sufficient for you, for My power is perfected in weakness. Therefore, I will rather gladly boast in my weaknesses, that the power of Christ may overshadow me. Because of this, I am pleased in weaknesses, in insults, in dire needs, in persecutions, in distresses, for the sake of Christ. For when I may be weak, then I am powerful” (2 Corinthians 12:7-10).
John Calvin comments correctly on Psalm 50:15 (not an endorsement of Calvin as a true Christian — see bolded “John Calvin” hyperlink):
“We are enjoined to pray in the day of trouble, but not with the understanding that we are to pray only then, for prayer is a duty incumbent upon us every day, and every moment of our lives. Be our situation ever so comfortable and exempt from disquietude, we must never cease to engage in the exercise of supplication … In affliction, however our faith is more severely tried, and there is a propriety in specifying it as the season of prayer; the prophet pointing us to God as the only resort and means of safety in the day of our urgent necessity” (Calvin).
There are times when true Christians are so overwhelmed in a day of distress that they posses barely enough strength to pray: HELP!